Matching Formulation to Delivery Method: Optimizing Biocompatibility, Release Kinetics, & Clinical Outcomes
- Â The importance of matching drug formulation specifically to the delivery route rather than using a one-size-fits-all approach, ensuring compatibility with intravitreal versus other ocular delivery methods
- Challenges in maintaining drug stability and bioactivity, especially for sensitive biologics and antibodies, without modifying the drug, preserving its therapeutic effect over time
- Addressing immune response concerns in the eye where materials must be biocompatible, minimizing inflammation near delicate retinal neurons to avoid vision deterioration
- Strategies to optimize release duration and dose by tuning formulations, including sustained release over months using adaptable gels and hydrogels that can be delivered with small gauge needles