As ophthalmology advances toward longer dosing intervals, extending the half-life of biologics has become essential to reducing treatment burden and improving patient outcomes. This workshop will explore historic lessons and current innovations in developing long-acting delivery systems, focusing on formulation strategies and preclinical considerations that shape successful translation. Participants will gain insight into stability optimization, depot design, and the regulatory mindset required to bring next-generation biologic delivery platforms to market.

Key Topics to be Explored:

• Review current challenges in biologic delivery, including molecular instability, aggregation, and degradation in ocular environments
• Analyze why limited progress has been made in developing long-acting delivery systems in ophthalmology
• Evaluate formulation opportunities for ocular biologics – including particles, implants, depots, and bioresponsive systems – and discuss their respective limitations in terms of stability, release control, and biocompatibility
• Discuss preclinical hurdles in sustained biologic delivery, including model selection and safety/efficacy evaluation Future gazing: a look into the next generation of delivery platforms