5 Advances in Biodegradable Platforms: Balancing Controlled Release, Safety, & Patient Convenience
- Exploration of degradable materials that clear completely from the eye, emphasizing biocompatibility, control over burst release, and the ability to implant repeatedly as needed for chronic conditions
- Learn about shear-thinning peptidic gels for fine-needle injectable vitreal delivery; composed entirely of short chains of natural amino acids having modular functional properties; delivers unmodified biologics, including proven antiangiogenic proteins
- Discover the formulation using industry-standard media at neutral pH and dissolution of a matrix that does not require hydrolysis of any covalent bonds
- Uncover drug retention and release rates tuneable by rational modification of gel structure, ionic and hydrophobic properties, and designed drug-peptide interactions; high capacity for large protein drugs