Selecting Optimal Gene Therapy Delivery Strategy to Maximise Efficacy, Safety & Patient Reach
8:30 am - Thursday 21st January 2027
- Compare intravitreal AAV delivery for secreted proteins versus subretinal surgery for intracellular targets, understanding which retinal cell populations each route can effectively transduce
- Explore emerging suprachoroidal gene therapy delivery that may offer a middle ground between surgical complexity and transduction efficiency for RPE and photoreceptor targets
- Evaluate novel capsid engineering strategies that enable efficient transduction from the vitreous while minimizing dose-dependent inflammation
