Exploring Toxicity & Risk Issues when Delivering to the Eye
Time: 8:00 am
day: Pre-Conference Workshop Day - WORKSHOP A
Details:
Ocular immune privilege has made it abundantly difficult to achieve localized sustained drug delivery due to the result of ocular inflammation. Immune responses may vary according to the mode of administration (subretinal vs. intravitreal vs. suprachoroidal) however, the eye is a sensitive organ that tends to severely reject foreign objects. The field struggles to find the optimum method to reduce, and eventually eliminate, inflammation.
Join this workshop to:
- Understanding the different modes of ophthalmic drug delivery; subconjunctival, intravitreal, peri-orbital, and subretinal
- Examining current ophthalmic drug delivery devices and chances of inflammation
- Overcoming the eye’s low tolerance for foreign substances to be able to cross its barriers and allow the drug to be safely administered to the retina with minimal ocular damage
- Reviewing recent high-profile device candidates in the clinic that failed due to toxicity issues
- Decreasing the risk of infections and retinal detachment caused by repeated injections into the retina when locally delivering into the retina
